Also called (Microsoft .NET Framework Hotfix Q322289), after installed breaks debugging for ASP and ASP.NET. It goes even further by preventing ASP.NET applications from working at all! This breakage seems to only happen on some servers.
The Fix: You are going to love this...
1. Uninstall the "Microsoft .NET Framework Hotfix Q322289 (English)" update from Add/Remove programs.
2. Then go to:
http://www.microsoft.com/Downloads/Release.asp?ReleaseID=39298
to download the same patch and reinstall it!
We have tested this and it works. Send the bill for the 30-45 minutes you will waste to Microsoft! Thanks Microsoft for the wonderful patch program!!!